In COPD, small bronchi are especially affected. Production of sputum increases especially in the bronchi, measuring 3 to 8 millimeters in diameter, that are occluded by tobacco products. Subsequently, the sputum solidifies and forms a mechanic plug. Hypertrophy (or swelling) develops in the cells responsible for sputum production, which we call goblet cells, in the small bronchioles, followed by hypertrophy of bronchial smooth muscle, and thus, the mucus accumulates and mechanically occludes the narrow bronchial lumen. Sputum may solidify and form mechanical plugs despite medications, expectorants and physiotherapies.

The mechanical plugs created by airways negatively affect the respiratory capacity of the patient, can lead to infections, and prevent availability of drugs in the small airways. Mechanical cleansing of the respiratory tract in patients with COPD and severe asthma allows remarkable recovery of respiratory functions, substantial regression of shortness of breath and normalization of the sputum. Although it is known that efficient bronchial cleansing eliminates shortness of breath, no practical method could be found to date.

Bronchus Desobstruction Treatment Technique developed by Prof. Yalçın Karakoca, M.D., opens the bronchial lumen, expectorates the sputum and heals the bronchial lumen that produces mucus excessively. Thus, it makes significant contribution to the solution of a very important problem in patients with COPD (Chronic Obstructive Pulmonary Disease) and severe asthma. In this COPD treatment technique, a bronchoscope is inserted into trachea under general anesthesia and all occluded bronchi are cleaned one by one with the help of a special device. This method opens the bronchi that are occluded due to COPD and thus, the patient regains the freedom of breathing. Bronchial patency treatments have been developed primarily to treat lung cancer. Tubes that must be filled with air are occluded by tumor in patients with lung cancer and by mucus and mucus producing cells in patients with COPD and severe asthma. The important issue is to perform the bronchial patency technique efficiently.