Professor Dr. Ömer Faruk Bayrak

Medical Genetics

Department: Medical Genetics

Expertise: Medical Genetics

Faculty and Year: Biology-2002

Place and Year of Birth: Erzurum / 1979


Place and Year of Doctor Associate Professor: Doctorate Selçuk University-2010

Place and Year of Assistant Professorship: Yeditepe University-2014

Abroad Education: Minesota University Department of Cardiology Stem Cell Research Laboratory

Foreign Languages: English

Professional Awards:

  1. Turkish Neurosurgical Society Congress 2007 Best 7th Presentation Award (M. Altaş, Ö.F. Bayrak, İ. Elmacı, ME Yalvac, F. Sahin. Detection of Angiotensin-Converting Enzyme I / D Gene Polymorphism in Patients Affected with Cerebral Cavernous malformations)

2nd Turkish Neurosurgical Society Congress 2008 Best 6th Presentation Award (Bayrak OF, Mut M, Ture U, Sahin F, Atlas M, Karatas OF, Yalvac ME, Ekici ID. 2008. Isolation, Characterization of Chordoma Cells and Chordoma of Some Chemotherapeutic Agents In vitro Demonstration of Effects on Cells)

3rd Medical Genetic Society Congress 2009 Poster 1st Poster Award (Eren H, Bayrak OF, Önal S, Multani A, Pathak S, Ittmann M, and Özen M, Role of Alternative Splice Variants of CDC25 Gene in Genomic Instability)

4th Medical Genetic Society Congress 2012 (Flag OF, Magli A, Perlingeiro RC. Best Presentation Award miRNA Roles of Embyonic Stem Cells in Mesoderm Development).

5th Turkish Neurosurgical Society Congress 2013 Best 5th Presentation Award (Bayrak OF, Güllüoğlu S, Aydemir E, Acar H, Atalay B, Demir Z, Sevli S, Chad J. Creighton CJ, Ittmann M, Şahin F, Özen M, Expression Profiling and Effects of miRNAs in Türe U. Chordomas

Number of Professional Publications: 32

Foreign Publications: 23

Citations: 148

International Proceedings: 11

National Proceedings: 14


  1. Articles published in international refereed journals: A1. Atasoy, M., Pirim, I., Flag, O., Ozdemir, S., Ikbal, M., Erdem, T., Aktas, A, “Association of HLA class I and class II alleles with psoriasis vulgaris in Turkish population Influence of type I and II psoriasis “, Saudi Medical Journal 373-376 (ISI), 373-376 pp., 2006, DOI: ISSN: 0379-5284 A2. Agar, G., Adiguzel, A., Baris, O., Sengul, M., Gulluce, M., Sahin, F., Flag, OF, “FAME and RAPD analysis of selected Vicia taxa from eastern Anatolia, Turkey”, Annales Botanici Fennici (ISI), 241-249 pp., 206, DOI: ISSN: 00033847 A3. Kahraman, M., Yazici, MM, Sahin, F., Flag, OF, Culha, M., “Reproducible surface-enhanced Raman scattering spectra of bacteria on aggregated silver nanoparticles”, Applied Spectroscopy (ISI), 479-485 pp. , 2007, DOI: 10.1366 / 000370207780807731 A4. Gercekcioglu R, Yilmaz N, Bayrak O.F, Sahin F., “Variation in Fatty Acid Composition of Tulameen Red Raspberry Seed Oil by The Application of Nitrogen Fertilizers and Organic Manure”, International Journal of Natural and Engineering Sciences, 59-64. pp., 2007 A5. Akgun, H., Berk, B., Demir Erol, D., Mercanoglu, G., Flag, OF, Caglayan, B., Dedeagac, A., Aksan Kurnaz, I., “Nitric oxide releasing derivatives of [(2 -chloroethyl) ureido] benzoic acid esters as potential antineoplastic agents “, Turkish Journal of Chemistry (ISI), 107-121 pp., 2009, DOI: 10.3906 / kim-0807-25 A6. Karakus, S., Guniz Kucukguzel, S., Kucukguzel, I., De Clercq, E., Pannecouque, C., Andrei, G., Snoeck, R., Sahin, F., Flag, OF, “Synthesis, antiviral N- (4-nitro-2-phenoxyphenyl) -methanesulfonamide “, European Journal of Medicinal Chemistry (ISI), 3591-3595 pp., 2009, DOI: 10.1016 / j.ejmech.2009.02. 030 A7. Flag, O. F., Aydemir, E., Sahin, F., “Retinoic acid induced chordomas as a model of differential therapy”, Saudi Medical Journal (ISI), 1236-1237. pp., 2009, DOI: 03795284 A8. Yalvac, ME, Ramazanoglu, M., Rizvanov, AA, Sahin, F., Flag, OF, Salli, U., Palotás, A., Kose, GT, “Isolation and characterization of stem cells derived from human third molar tooth germs of young adults: implications in neo-vascularization, osteo-, adipo- and neurogenesis “, Pharmacogenomics Journal, (ISI), 105-113 pp., 2009, DOI: 10.1038 / tpj.2009.40. A9. Aydin, O., Altaş, M., Kahraman, M., Bayrak, OF, Çulha, M., “Surface-enhanced Raman scattering using different brain tissues and tumors”, Applied Spectroscopy (ISI), 1095-1100 pp ., 2009, DOI: 10.1366 / 000370209789553219 A10. Colak, KM, Keles, A., Flag, OF, Koseoglu, M., Sahin, F., “Study of cytotoxicity of six root canal sealing dental materials”, Materials Research Innovations, 415-420 pp., 2009, DOI: 10.1179 / 143289109X12494867167161 A11. Karapinar-Kazandaǧ, M., Tanalp, J., Bayrak, Ö.F., Sunay, H., Bayirli, G., “Microleakage of various root filling systems using glucose filtration analysis”, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology (ISI), 96-102 pp., 2010, DOI: 10.1016 / tripleo.2010.01.009 A12. Altas, M., Flag OF, Cerci, A., Isik, N., Celik, M., Culha, M., Sahin, F., Elmaci, I., “Angiotensin-Converting Enzyme I / D Gene Polymorphism in Patients with Familial Multiple Cerebral Cavernous Malformations “, Journal of Clinical Neuroscience, (ISI), 1034-1037. pp., 2010, DOI: 10.1016 / j.jocn 2009.12.002 A13. Yalvac, ME, Ramazanoglu, M, Tekguc, M, Flag, OF, Shafigullina, AK, Salafutdinov II, Blatt NL, Kiyasov, AP, Sahin, F, Palotás, A, Rizvanov, AA, “Human Tooth Germ Stem Cells Preserve Neuro -Protective Effects after Long-Term Cryo-Preservation “, Current neurovascular research (ISI), 49-58 pp., 2010, DOI: 10.2174 / 156720210790820181 A14. Esra Tatar E, Kucukguzel I, Kucukguzel SG, Demircan FY, De Clercq E, Andrei G, Snoeck R, Pannecouque C, Sahin F, Flag OF ,, “Synthesis, Anti-Tuberculosis and Antiviral Activity of Novel 2-isonicotinoylhydrazono-5- arylidene-4-thiazolidinones “, International Journal of Drug Design and Discovery, 19-32 pp., 2010 A15. Turkekul I, Yilmaz N, Sahin F, Flag OF ,, “Fatty Acid Composition of Six Mushroom Samples of Black Sea Region of Turkey”, Asian Journal of Chemistry (ISI), 1479-1486 pp., 2010, DOI: ISSN: 0970 -7077 A16. Altas M, Flag OF, Ayan E, Bolukbasi F, Silav G, Coskun KK, Culha M, Sahin F, Sevli S, Elmaci I ,, “The Effect of Polymorphisms in the Promoter Region of the MMp-1 Gene on The Occurence and Invasivness of Hypophyseal Adenoma “, Acta Neurochirurgica, (ISI), 1611-1617 pp., 2010, DOI: 10.1007 / s00701-010-0671-0 A17. Flag OF, Aydemir E, Gulluoglu S, Sahin F, Sevli S, Yalvac ME, Acar H, Ozen M ,, “The Effects of Chemotherapeutic Agents on Differentiated Chordoma Cells”, Journal of Neurosurgery Spine, (ISI), 620-624 pp ., 2011, DOI: 10.3171 / 2011.7.SPINE10798 A18. Karapinar-Kazandag M, Bayrak OF, Yalvac ME, Ersev H. Tanalp J, Sahin F, Bayirli G ,, “Cytotoxicity of 5 endodontic Sealers on L929 Cell Line and Human Dental Pulp Cells.”, International Endodondic Journal (ISI), 626 -634 pp., 2011, DOI: 10.1111 / j.1365-2591.2011.01863.x A19. Aydemir E, Flag OF, Sahin F, Atalay B, Kose GT, Ozen M, Sevli S, Dalan AB, Yalvac ME, Accuracy T, Ture U ,, “Characterization of Cancer Stem-Like Cells in Chordoma.”, Journal of Neurosurgery (ISI), 810-820 pp., 2012, DOI: 10.3171 / 2011.12.JNS11430 A20. Karaca, E, Karakoc-Aydiner, E, Flag, OF, Keles, S, Sevli, S, Barlan, IB, Yuksel, A, Chatila, TA, Ozen, M., “Identification of a novel mutation in ZAP70 and prenatal diagnosis in Gene (ISI), 189-193 pp., 2013, DOI: 10.1016 / j.gene.2012.10.062 A21. Yilmaz, N, Turkekul, I, Bulut, S, Sahin, F, Flag, OF, “Fatty acid composition in the mushroom species collected from the Middle Black Sea region of Turkey”, Asian Journal of Chemistry (ISI), 1216-1220 pp ., 2013, DOI: ISSN: 09707077 A22. Altas M, Bayrak OF, Serefhan A, Silav G, Coskun KK, Cerci A, Isik N, Elmaci E., “Investigation of ACE genome Insertion / Deletion correlation with Immunohistochemical Profile in pituitary adenomas”, Turkish Journal of Neurosurgery (ISI), In publication pp., 2013, DOI: 10.5137 / 1019-5149.JTN.7423-12.0 A23. Flag, Omer Faruk; Gulluoglu, Sukru; Aydemir, Esra; Ture, Ugur; Acar, Hasan; Atalay, Basar; Demir, Zeynel; Sevli, Serhat; Creighton, Chad J .; Ittmann, Michael; Sahin, Fikrettin; B. Presented at international scientific meetings and published in the proceedings: B1. Kahraman, M., Yazici, MM, Sahin, F., Bayrak, OF, Topcu, E., Culha, M., 7th Workshop on Biosensors and BioAnalytical Mu-Techniques for Environmental and Clinical Analysis Conference “International Journal of Environmental Analytical Chemistry, “Towards single-microorganism detection using surface-enhanced Raman spectroscopy” in the proceeding book, 87 (10-11), pp. 763-770. pp., Kusadasi Turkey in September 2006 B2. Yalvac, ME, Ramazanoglu, M., Bayrak, OF, Sahin, F., Kose, GT, FEBS Conference “FEBS JOURNAL Volume 271” in the booklet “Multipotent stem cells derived from human follicle show osteogenic and neurogenic differentiation”, 91 pp., Athens Greece, July 2008 B3. Ozdemir, N., Saygili, H., Sahin, F., Karsavuran, Y., Bayrak, O.F., Oral, B., 2nd International Symposium on Tomato Diseases Conference “II INTERNATIONAL SYMPOSIUM ON TOMATO DISEASES Book Series: Acta Horticultura to “the Report booklet” Host range and genetic characterization of a phytoplasma causing tomato is stolbur disease in Turkey “, 808255-261 pp., Kusadasi Turkey, January 2009 B4. Culha, M., Karatas, OF, Aydin, O., Kahraman, M., Kesero, K., Sayin, I., Flag, OF, Progress Progress in Biomedical Optics and Imaging – Proceedings of SPIE, 7192, art. no. “Towards PCR-free mutation detection based on surface-enhanced Raman scattering”, DOI: 10.1117 / 12.808267 pp., CA USA, 2009 B5. Uzumcu, A., Tekguc, M., Sevli, S., Flag, OF, Ozen, M., “The ROLE OF MICRORNA (miRNA) s AS A NOVEL TOOL IN CANCER DIAGNOSIS AND THERAPY” in the International Union of Biochemistry and Molecular Biology conference, “IUBMB LIFE”, 298 pp., Shanghai China, March 2009 B6 Duzenli, S., Bayrak, OF, Yegin, I., CD LOSS OF HETEROZYGOSITY (LOH) OF THE CDH1 GENE IN SPORADIC GASTRIC ADENOCARCINOMAS ındaki in the I IUBMB LIFE bildiri leaflet “, 6-375 pp., Shanghai CHINA, March 2009 B7. Aydemir, E., Bayrak, OF, Ozen, M., Sahin, F., 35th Congress of the Federation-of-European-Biochemical-Societies conference “The effects of chemotherapeutic agents on differentiated chordoma cells” in the “FEBS JOURNAL” leaflet, 1 61 pp., Gothenburg Sweden, July 2010 B8. Yalvac, ME, Flag, OF, Kose, GT, Sahin, F., 18th Annual BSHI Conference, conference “INTERNATIONAL JOURNAL OF IMMUNOGENETICS Volume: 34 Issue: 4” leaflet “Neuron-like cells derived from human cervical cancer HeLa cells “, 293 pp., Birmingham, UK, September 2007 B9. Bayrak, OF, Sahin, F., Pirim, I., Yalvac, ME, Izbirak, CD, 31st Congress of the Federation-of-European-Biochemical-Societies conference “FEBS JOURNAL Volume: 273 Supplement: 1” in the proceedings “Relationship between a single nucleotide polymorphism in the matrix metalloproteinase-1 promoter and ovarian cancer”, 88-89 pp., Istanbul, Turkey, June 2006 C. international books or book chapters: D. national peer-reviewed articles published in journals: D1. Gercekcioglu R, Yilmaz N, Bayrak OF, Sahin F ,, “Variation in Fatty Acid Composition of Tulameen Red Raspberry Seed Oil by The Application of Nitrogen Fertilizers and Organic Manure”, International Journal of Natural and Engineering Sciences, 59-64 pp., 2007 D2. Exit, P., Küçükgüzel, Ş.G., Küçükgüzel, İ, Rollas, S., De Clercq, E., Pannecouque, C., Andrei, G., Snoeck, R., Şahin, F., Flag, OF, “Synthesis and evaluation of antiviral, antitubercular and anticancer activities of some novel thioureas derived from 4-aminobenzohydrazide hydrazones”, Marmara Pharmaceutical Journal, 13-20 pp., 2010 F. Other publications: F1. Journal of Neurosurgery Volume 118, Issue 4, April 2013, Page 914 Bayrak, Ö.F., Gulluoglu, S., Aydemir, E., Ture, U, DOI: 10.3171 / 2012.3.JNS12478 F2. Journal of Neurosurgery: Bayrak, Ö.F., Gulluoglu, S., Aydemir, E., SpineFebruary 15, 2013; DOI: 10.3171 / 2012.2.SPINE111060.


Tasks in Projects:

  1. TUBITAK Executive 3503 (Career Project) 01.04.2013-01.04.2016 Isolation of Cancer Stem Cells from Chordoma Cell Cultures and Xenograft Models: Investigation of Mirna Profile in Stem Cells (112S485) 2. TUBITAK Supervisor 1001 01.08.2013- Genotoxic and Epigenetic Breast Epithelial Cells Investigation of Bioactivity of Dioxins and Xenoestrogens in Breast Milk with Changes in Reporter Gene Level (113S155)
  2. TÜBİTAK Expert 1003 15.12.2012-15.12.2014 Synthesis, Functionalization and Development of New Fields of Use of Boron Nitride Nanotubes with New Methods (112M480)
  3. TUBITAK Expert 1001 15.10.2012-15.10.2014 Development of DNA Origami Based Nanocarrier Tools 112T280
  4. TÜBİTAK Expert 1001 01.07.2007-01.07.2009 Mentha Longifolia L. Hudson ssp., Which has Antimutagen and Anticarcinogenic Properties in Erzurum Region. Longifolia and Origanum Vulgare ssp. Isolation and Identification of Active Substances from Vulgare Species
  5. TÜBİTAK Expert 1001 01.01.2006-01.01.2008 Development of New Nanostructured Surfaces for Raman Scatter-Based Microorganism Diagnosis with Surface Enhancement
  6. Experts TUBITAK in Turkey in 1001 01.09.2005-01.09.2008 Cancer Causing Potato Synchytrium endobioticum (SCHLİB.) Perc’n Pathological and Molecular Diagnosis: Determination of effective strategies to fight the disease with
  7. Yeditepe University BAP Executive 2009-2010 Identification of microRNAs and related transcripts with expression differences in human chordomas, investigation of the potential of using chordoma in molecular diagnosis and treatment
  8. Yeditepe University BAP Expert 2013-2015 Determination of miRNA expression profile in atypical meningiomas and investigating the effects of related miRNAs.

Association Club Memberships:

  1. Medical Genetic Society
  2. Molecular Cancer Association
  3. Biochemistry Association
  4. European Association for Cancer Research
  5. European Cytogenetic Association